Drug Information

Drug General Information
Drug ID
D07VZV
Former ID
DIB004109
Drug Name
N-0861
Synonyms
WRC-0006; WRC-0007
Drug Type
Small molecular drug
Indication Cardiac disease [ICD10:I00-I99] Discontinued in Phase 3 [545445]
Company
Aderis Pharmaceuticals Inc
Formula
C13H17N5
Canonical SMILES
c12ncn(c1ncnc2N[C@H]1[C@H]2C[C@@H](C1)CC2)C
PubChem Compound ID
6918211
Target and Pathway
Target(s) Adenosine A1 receptor Target Info Antagonist [527141]
KEGG Pathway cGMP-PKG signaling pathway
cAMP signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
Morphine addiction
NetPath Pathway TCR Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Adenosine P1 receptors
G alpha (i) signalling events
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 545445Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003285)
Ref 527141N-0861 selectively antagonizes adenosine A1 receptors in vivo. Eur J Pharmacol. 1992 May 27;216(1):9-16.

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