Drug Information

Drug General Information
Drug ID
D07UCQ
Former ID
DNC010204
Drug Name
Sodium phenylaminomethanesulfonate
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530399]
Formula
C7H8NNaO3S
Canonical SMILES
C1=CC=C(C=C1)NCS(=O)(=O)[O-].[Na+]
InChI
1S/C7H9NO3S.Na/c9-12(10,11)6-8-7-4-2-1-3-5-7;/h1-5,8H,6H2,(H,9,10,11);/q;+1/p-1
InChIKey
AJSINQAAKNYUDA-UHFFFAOYSA-M
PubChem Compound ID
23680200
Target and Pathway
Target(s) Carbonic anhydrase IX Target Info Inhibitor [530399]
Carbonic anhydrase XII Target Info Inhibitor [530399]
KEGG Pathway Nitrogen metabolismhsa00910:Nitrogen metabolism
NetPath Pathway TGF_beta_Receptor Signaling Pathway
Pathway Interaction Database HIF-1-alpha transcription factor network
Reactome Regulation of gene expression by Hypoxia-inducible Factor
Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxide
WikiPathways Vitamin D Receptor Pathway
Reversible Hydration of Carbon Dioxide
Regulation of Hypoxia-inducible Factor (HIF) by OxygenWP2770:Reversible Hydration of Carbon Dioxide
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in leukocytes - TarBase
miR-targeted genes in epithelium - TarBase
References
Ref 530399Bioorg Med Chem. 2009 Oct 15;17(20):7093-9. Epub 2009 Sep 6.Carbonic anhydrase inhibitors. Diazenylbenzenesulfonamides are potent and selective inhibitors of the tumor-associated isozymes IX and XIIover the cytosolic isoforms I and II.
Ref 530399Bioorg Med Chem. 2009 Oct 15;17(20):7093-9. Epub 2009 Sep 6.Carbonic anhydrase inhibitors. Diazenylbenzenesulfonamides are potent and selective inhibitors of the tumor-associated isozymes IX and XIIover the cytosolic isoforms I and II.

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