Drug Information

Drug General Information
Drug ID
D07TKE
Former ID
DNC007495
Drug Name
4-phenyl-1-(3-phenylpropyl)piperidin-4-ol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528785]
Formula
C20H25NO
Canonical SMILES
C1CN(CCC1(C2=CC=CC=C2)O)CCCC3=CC=CC=C3
InChI
1S/C20H25NO/c22-20(19-11-5-2-6-12-19)13-16-21(17-14-20)15-7-10-18-8-3-1-4-9-18/h1-6,8-9,11-12,22H,7,10,13-17H2
InChIKey
ZZUJERGWKSXINO-UHFFFAOYSA-N
PubChem Compound ID
15723894
Target and Pathway
Target(s) Nociceptin receptor Target Info Inhibitor [528785]
KEGG Pathway Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 528785Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1.
Ref 528785Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1.

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