Drug Information

Drug General Information
Drug ID
D07SZJ
Former ID
DIB014734
Drug Name
A-75169
Synonyms
A-74324; A-74325
Indication Glaucoma [ICD9: 365; ICD10:H40-H42] Terminated [545494]
Company
Abbott Laboratories
Canonical SMILES
c12c(cc(cc2)O)CCCC1CN(CCc1ccccc1)C
CAS Number
CAS 125067-40-5
Target and Pathway
Target(s) Alpha-2C adrenergic receptor Target Info Modulator [550028]
KEGG Pathway cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
G alpha (z) signalling events
Surfactant metabolism
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Platelet Aggregation (Plug Formation)
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signaling
References
Ref 545494Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003469)
Ref 550028A-75169 HCI: Pharmacological profile and ocular pharmacology studies of a new alpha-2 antagonist. Drug Development Research Volume 28, Issue 1, pages 56-64, January 1993.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.