Drug Information

Drug General Information
Drug ID
D07RMP
Former ID
DNC000825
Drug Name
J-113397
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539046]
Formula
C24H37N3O2
InChI
InChI=1S/C24H37N3O2/c1-2-26-22-12-8-9-13-23(22)27(24(26)29)21-14-15-25(17-20(21)18-28)16-19-10-6-4-3-5-7-11-19/h8-9,12-13,19-21,28H,2-7,10-11,14-18H2,1H3/t20-,21+/m0/s1
InChIKey
MBGVUMXBUGIIBQ-LEWJYISDSA-N
PubChem Compound ID
5311194
PubChem Substance ID
7979669, 11056328, 14830462, 39340903, 49684203, 53837751, 57359383, 80610886, 103392033, 103982930, 114155511, 128570833, 134339497, 134340142, 135650442, 135698674, 139947055, 198971131, 223369923, 227143834
Target and Pathway
Target(s) Nociceptin receptor Target Info Antagonist [535360], [535745], [536893]
KEGG Pathway Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 539046(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1691).
Ref 535360Nociceptin receptor antagonists display antidepressant-like properties in the mouse forced swimming test. Naunyn Schmiedebergs Arch Pharmacol. 2002 Feb;365(2):164-7. Epub 2001 Dec 20.
Ref 535745The nociceptin receptor as a potential target in drug design. Drug News Perspect. 2001 Aug;14(6):335-45.
Ref 536893Nocistatin and nociceptin given centrally induce opioid-mediated gastric mucosal protection. Peptides. 2008 Dec;29(12):2257-65. Epub 2008 Sep 26.

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