Drug Information

Drug General Information
Drug ID
D07QQY
Former ID
DIB018124
Drug Name
[11C]DTBZ
Synonyms
[11C]-DTBZ ; [11C]-DTBZ (PET ligand); dihydrotetrabenazine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467849]
Formula
C20H31NO3
InChI
InChI=1S/C20H28NO3/c1-13(2)8-15-12-21-7-6-14-9-18(23-4)19(24-5)10-16(14)20(21,3)11-17(15)22/h9-10,13,15,17,22H,6-8,11-12H2,1-3,5H3/t15-,17-,20-/m0/s1/i4-1
InChIKey
LCUNKBCUJJTZNQ-VEFADGFBSA-N
PubChem Compound ID
73755103
Target and Pathway
Target(s) Synaptic vesicle amine transporter Target Info Inhibitor [543358]
KEGG Pathway Synaptic vesicle cycle
Serotonergic synapse
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Amphetamine addiction
Alcoholism
PANTHER Pathway Adrenaline and noradrenaline biosynthesis
5HT1 type receptor mediated signaling pathway
5HT2 type receptor mediated signaling pathway
5HT3 type receptor mediated signaling pathway
5HT4 type receptor mediated signaling pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
CCKR signaling map ST
Reactome Norepinephrine Neurotransmitter Release Cycle
Na+/Cl- dependent neurotransmitter transporters
WikiPathways Dopaminergic Neurogenesis
Synaptic Vesicle Pathway
Neurotransmitter Release Cycle
Nicotine Activity on Dopaminergic Neurons
References
Ref 467849(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4608).
Ref 543358(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1012).

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