Drug Information

Drug General Information
Drug ID
D07QMY
Former ID
DIB020361
Drug Name
ML 10375
Synonyms
ML-10375; ML10375
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539614]
Formula
C17H25ClN2O3
InChI
InChI=1S/C17H25ClN2O3/c1-11-6-12(2)10-20(9-11)4-5-23-17(21)13-7-14(18)15(19)8-16(13)22-3/h7-8,11-12H,4-6,9-10,19H2,1-3H3
InChIKey
BUEFUOFMOXJXAR-UHFFFAOYSA-N
PubChem Compound ID
9905972
PubChem Substance ID
14875703, 24187461, 45977638, 80017938, 85221200, 103406607, 103952664, 127568693, 135650620, 229006687
Target and Pathway
Target(s) 5-hydroxytryptamine 4 receptor Target Info Antagonist [525774]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT4 type receptor mediated signaling pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 4 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 539614(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 249).
Ref 525774Exploration of the ligand binding site of the human 5-HT(4) receptor by site-directed mutagenesis and molecular modeling. Br J Pharmacol. 2000 Jun;130(3):527-38.

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