Drug Information

Drug General Information
Drug ID
D07PSW
Former ID
DNC004077
Drug Name
N-(4-Phenyl-pyridin-2-yl)-guanidine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [526236]
Formula
C12H12N4
Canonical SMILES
C1=CC=C(C=C1)C2=CC(=NC=C2)N=C(N)N
InChI
1S/C12H12N4/c13-12(14)16-11-8-10(6-7-15-11)9-4-2-1-3-5-9/h1-8H,(H4,13,14,15,16)
InChIKey
LQYVUDQYWIIZAV-UHFFFAOYSA-N
PubChem Compound ID
10219978
Target and Pathway
Target(s) Tissue-type plasminogen activator Target Info Inhibitor [526236]
KEGG Pathway Complement and coagulation cascades
Transcriptional misregulation in cancer
NetPath Pathway IL5 Signaling Pathway
PANTHER Pathway Blood coagulation
Plasminogen activating cascade
Pathway Interaction Database amb2 Integrin signaling
Beta2 integrin cell surface interactions
PathWhiz Pathway Coagulation
Reactome Dissolution of Fibrin Clot
WikiPathways Senescence and Autophagy in Cancer
Complement and Coagulation Cascades
Endochondral Ossification
Blood Clotting Cascade
Dissolution of Fibrin Clot
Folate Metabolism
Vitamin B12 Metabolism
Selenium Micronutrient Network
References
Ref 526236Bioorg Med Chem Lett. 2002 Jan 21;12(2):181-4.Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 1: 2-Pyridinylguanidines.
Ref 526236Bioorg Med Chem Lett. 2002 Jan 21;12(2):181-4.Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 1: 2-Pyridinylguanidines.

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