Drug Information

Drug General Information
Drug ID
D07PMG
Former ID
DIB004594
Drug Name
Afeletecan
Synonyms
Afeletecan hydrochloride; Camptothecin glycoconjugate, Bayer; Topoisomerase I inhibitors, Bayer
Drug Type
Small molecular drug
Indication Breast cancer [ICD9: 174, 175; ICD10:C50] Phase 1 [547154]
Company
Bayer AG
Formula
C45H49N7O11S
Canonical SMILES
n12c(c3c(C2)cc2c(n3)cccc2)cc2c(c1=O)COC(=O)[C@]2(OC(=O)<br />[C@@H](NC(=O)[C@@H](NC(=S)Nc1ccc(O[C@@H]2[C@H]([C@@H]([<br />C@@H]([C@@H](O2)C)O)OC)O)cc1)Cc1nc[nH]c1)C(C)C)CC
PubChem Compound ID
9941008
Target and Pathway
Target(s) Toposisomerase-1 Target Info Inhibitor [544231]
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway DNA replication
Pathway Interaction Database Caspase Cascade in Apoptosis
WikiPathways Integrated Pancreatic Cancer Pathway
References
Ref 547154Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013469)
Ref 544231The fate of camptothecin glycoconjugate: report of a clinical hold during a phase II study of BAY 56-3722 (formerly BAY 38-3441), in patients with recurrent or metastatic colorectal cancer resistant/refractory to irinotecan. Invest New Drugs. 2012 June; 30(3): 1208-1210.

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