Drug Information

Drug General Information
Drug ID
D07OAF
Former ID
DIB018721
Drug Name
A61603
Synonyms
A-61603; A 61603
Drug Type
Small molecular drug
Indication Discovery agent Investigative [468030]
Formula
C14H19N3O3S
InChI
InChI=1S/C14H19N3O3S/c1-21(19,20)17-13-10-3-2-4-11(14-15-7-8-16-14)9(10)5-6-12(13)18/h5-6,11,17-18H,2-4,7-8H2,1H3,(H,15,16)
InChIKey
OQFCXJDXHCDLHX-UHFFFAOYSA-N
PubChem Compound ID
4038180
PubChem Substance ID
5937365, 7978621, 9443810, 14752118, 26752047, 35298653, 57356686, 80875551, 85208934, 85788131, 92098463, 103332129, 104011967, 112572397, 128845856, 135649874, 142531119, 225012789, 234322616
Target and Pathway
Target(s) Alpha-2C adrenergic receptor Target Info Agonist [533660]
KEGG Pathway cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
G alpha (z) signalling events
Surfactant metabolism
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Platelet Aggregation (Plug Formation)
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signaling
References
Ref 468030(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 480).
Ref 533660A-61603, a potent alpha 1-adrenergic receptor agonist, selective for the alpha 1A receptor subtype. J Pharmacol Exp Ther. 1995 Jul;274(1):97-103.

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