Drug Information

Drug General Information
Drug ID
D07NPQ
Former ID
DIB018401
Drug Name
[3H]RS 57639
Synonyms
RS57639
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539519]
Formula
C25H31ClN2O5
InChI
InChI=1S/C25H31ClN2O5/c1-30-23-15-21(27)20(26)14-19(23)25(29)33-16-18-6-9-28(10-7-18)8-2-3-17-4-5-22-24(13-17)32-12-11-31-22/h4-5,13-15,18H,2-3,6-12,16,27H2,1H3
InChIKey
AJVNZBQUOHOEQO-UHFFFAOYSA-N
PubChem Compound ID
5311417
PubChem Substance ID
7980546, 11056490, 14761070, 39341094, 47510128, 47880158, 53131167, 114156037, 135650945, 135651199, 242502004
Target and Pathway
Target(s) 5-hydroxytryptamine 4 receptor Target Info Agonist [534429]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT4 type receptor mediated signaling pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 4 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 539519(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 239).
Ref 534429[3H]RS 57639, a high affinity, selective 5-HT4 receptor partial agonist, specifically labels guinea-pig striatal and rat cloned (5-HT4S and 5-HT4L) receptors. Neuropharmacology. 1997 Apr-May;36(4-5):671-9.

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