Drug Information

Drug General Information
Drug ID
D07LDP
Former ID
DIB020003
Drug Name
hexahydrosiladifenidol
Synonyms
Hhsi-difenidol; hexahydro-sila-diphenidol; GNF-Pf-5565
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540103]
Formula
C20H33NOSi
InChI
InChI=1S/C20H33NOSi/c22-23(19-11-4-1-5-12-19,20-13-6-2-7-14-20)18-10-17-21-15-8-3-9-16-21/h1,4-5,11-12,20,22H,2-3,6-10,13-18H2
InChIKey
QTBCATBNRIYMPB-UHFFFAOYSA-N
PubChem Compound ID
3602
PubChem Substance ID
5541062, 8152271, 15421631, 29222728, 48185193, 48334724, 50065432, 57321889, 77875681, 81093295, 85209442, 89449652, 90530468, 92729671, 103816049, 104303983, 106230727, 117557523, 117745707, 126407651, 131331981, 131342373, 135079083, 135652751, 140372922, 163213354, 164235785, 169824515, 179293708, 241169484, 247194615
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M3 Target Info Antagonist [533335]
Muscarinic receptor Target Info Antagonist [533335]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Regulation of actin cytoskeleton
Insulin secretion
Salivary secretion
Gastric acid secretion
Pancreatic secretionhsa04020:Calcium signaling pathway
cAMP signaling pathway
PI3K-Akt signaling pathway
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
PathWhiz Pathway Gastric Acid ProductionPW000564:Muscle/Heart Contraction
Reactome Muscarinic acetylcholine receptors
Acetylcholine regulates insulin secretion
G alpha (q) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP58:Monoamine GPCRs
Secretion of Hydrochloric Acid in Parietal Cells
References
Ref 540103(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 310).
Ref 533335Antagonist binding properties of five cloned muscarinic receptors expressed in CHO-K1 cells. Mol Pharmacol. 1989 Apr;35(4):469-76.

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