Drug Information

Drug General Information
Drug ID
D07KIB
Former ID
DIB012099
Drug Name
4-fluoroselegiline
Synonyms
CH-175; SR-96516; P-Fluoro-Selegiline; P-Fluoro-Selegiline hydrochloride
Indication Dementia [ICD9: 290-294; ICD10:F01-F07] Investigative [533786]
Company
Chinoin Gyogyszer Es Vegyeszeti
Canonical SMILES
C(#C)CN([C@@H](Cc1ccc(F)cc1)C)C
Target and Pathway
Target(s) Amine oxidase [flavin-containing] B Target Info Modulator [533786]
BioCyc Pathway Superpathway of tryptophan utilization
Tryptophan degradation via tryptamine
Dopamine degradation
Putrescine degradation III
Noradrenaline and adrenaline degradation
KEGG Pathway Glycine, serine and threonine metabolism
Arginine and proline metabolism
Histidine metabolism
Tyrosine metabolism
Phenylalanine metabolism
Tryptophan metabolism
Drug metabolism - cytochrome P450
Metabolic pathways
Serotonergic synapse
Dopaminergic synapse
Cocaine addiction
Amphetamine addiction
Alcoholism
PANTHER Pathway Adrenaline and noradrenaline biosynthesis
5-Hydroxytryptamine degredation
Dopamine receptor mediated signaling pathway
Pathway Interaction Database Alpha-synuclein signaling
WikiPathways Tryptophan metabolism
Dopamine metabolism
Phase 1 - Functionalization of compounds
References
Ref 533786Multiple, small dose administration of (-)deprenyl enhances catecholaminergic activity and diminishes serotoninergic activity in the brain and these effects are unrelated to MAO-B inhibition. Arch Int Pharmacodyn Ther. 1994 Jul-Aug;328(1):1-15.
Ref 533786Multiple, small dose administration of (-)deprenyl enhances catecholaminergic activity and diminishes serotoninergic activity in the brain and these effects are unrelated to MAO-B inhibition. Arch Int Pharmacodyn Ther. 1994 Jul-Aug;328(1):1-15.

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