Drug Information

Drug General Information
Drug ID
D07JMN
Former ID
DNC009124
Drug Name
1-(pyridin-2-yl)piperazine
Synonyms
1-Pyridin-2-yl-piperazine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [533509]
Formula
C9H13N3
Canonical SMILES
C1CN(CCN1)C2=CC=CC=N2
InChI
1S/C9H13N3/c1-2-4-11-9(3-1)12-7-5-10-6-8-12/h1-4,10H,5-8H2
InChIKey
GZRKXKUVVPSREJ-UHFFFAOYSA-N
PubChem Compound ID
94459
Target and Pathway
Target(s) Phospholipase D1 Target Info Inhibitor [530029]
Alpha-2A adrenergic receptor Target Info Inhibitor [533509]
Alpha-1D adrenergic receptor Target Info Inhibitor [533509]
Alpha-1A adrenergic receptor Target Info Inhibitor [533509]
Alpha-2B adrenergic receptor Target Info Inhibitor [533509]
BioCyc Pathway Phospholipases
KEGG Pathway Glycerophospholipid metabolism
Ether lipid metabolism
Metabolic pathways
Ras signaling pathway
cAMP signaling pathway
Sphingolipid signaling pathway
Endocytosis
Fc gamma R-mediated phagocytosis
Glutamatergic synapse
GnRH signaling pathway
Pathways in cancer
Pancreatic cancer
Choline metabolism in cancerhsa04022:cGMP-PKG signaling pathway
Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretionhsa04020:Calcium signaling pathway
AMPK signaling pathway
Salivary secretionhsa04022:cGMP-PKG signaling pathway
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway Angiogenesis
Ras PathwayP00002:Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Pathway Interaction Database RhoA signaling pathway
Arf6 trafficking events
CDC42 signaling events
Arf6 downstream pathway
mTOR signaling pathway
ErbB1 downstream signaling
IL8- and CXCR1-mediated signaling events
Alpha-synuclein signaling
Reactome Role of phospholipids in phagocytosisR-HSA-390696:Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
G alpha (z) signalling events
Surfactant metabolismR-HSA-390696:Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling eventsR-HSA-390696:Adrenoceptors
WikiPathways EGF/EGFR Signaling Pathway
TSH signaling pathwayWP58:Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Platelet Aggregation (Plug Formation)
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signalingWP58:Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR downstream signaling
GPCRs, OtherWP58:Monoamine GPCRs
Endothelin Pathways
AMPK SignalingWP58:Monoamine GPCRs
References
Ref 533509J Med Chem. 1984 Sep;27(9):1182-5.Adrenoceptor and tetrabenazine antagonism activities of some pyridinyltetrahydropyridines.
Ref 530029Bioorg Med Chem Lett. 2009 Apr 15;19(8):2240-3. Epub 2009 Mar 6.Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part II. Identification of the 1,3,8-triazaspiro[4,5]decan-4-one privileged structure that engenders PLD2 selectivity.
Ref 533509J Med Chem. 1984 Sep;27(9):1182-5.Adrenoceptor and tetrabenazine antagonism activities of some pyridinyltetrahydropyridines.

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