Drug Information

Drug General Information
Drug ID
D07JMB
Former ID
DNC007256
Drug Name
8-aza-11-deoxyprostaglandin E1
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527306]
Formula
C19H33NO4
Canonical SMILES
CCCCCC(C=CC1CCC(=O)N1CCCCCCC(=O)O)O
InChI
1S/C19H33NO4/c1-2-3-6-9-17(21)13-11-16-12-14-18(22)20(16)15-8-5-4-7-10-19(23)24/h11,13,16-17,21H,2-10,12,14-15H2,1H3,(H,23,24)/b13-11+/t16-,17-/m0/s1
InChIKey
XOPMUDZOEKPBQZ-NSNJOPQOSA-N
PubChem Compound ID
44289922
Target and Pathway
Target(s) Prostaglandin E2 receptor, EP4 subtype Target Info Inhibitor [527306]
KEGG Pathway Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
Renin secretion
Pathways in cancer
NetPath Pathway FSH Signaling Pathway
IL2 Signaling Pathway
IL4 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Reactome Prostanoid ligand receptors
G alpha (s) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Vitamin D Receptor Pathway
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 527306J Med Chem. 2004 Dec 2;47(25):6124-7.Lactams as EP4 prostanoid receptor agonists. 3. Discovery of N-ethylbenzoic acid 2-pyrrolidinones as subtype selective agents.
Ref 527306J Med Chem. 2004 Dec 2;47(25):6124-7.Lactams as EP4 prostanoid receptor agonists. 3. Discovery of N-ethylbenzoic acid 2-pyrrolidinones as subtype selective agents.

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