Drug Information

Drug General Information
Drug ID
D07JCI
Former ID
DIB012035
Drug Name
MCHR1 antagonists
Synonyms
Melanin-concentrating hormone receptor 1 antagonists (obesity); Melanin-concentrating hormone receptor 1 antagonists (obesity), AstraZeneca
Indication Obesity [ICD9: 278; ICD10:E66] Investigative [552119]
Company
AstraZeneca plc
Canonical SMILES
C(=O)(COc1cc(ccc1)Cl)NC1CCN(CC1)Cc1cn(cc1)c1ccc(cc1)OC(<br />F)(F)F
Target and Pathway
Target(s) Melanin-concentrating hormone receptor 1 Target Info Antagonist [543715]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 552119Melanin concentrating hormone receptor 1 (MCHR1) antagonists-Still a viable approach for obesity treatment? Bioorg Med Chem Lett. 2012 Oct 1;22(19):6039-47
Ref 543715(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 280).

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