TTD | Drug: D07JAL

Drug General Information
Drug ID	D07JAL
Former ID	DIB018076
Drug Name	(+/-)-trans-H2-PAT
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[538720]
Formula	C18H21N
InChI	InChI=1S/C18H21N/c1-19(2)16-12-15-10-6-7-11-17(15)18(13-16)14-8-4-3-5-9-14/h3-11,16,18H,12-13H2,1-2H3/t16-,18-/m1/s1
InChIKey	DXJUCAUQIHNOAF-SJLPKXTDSA-N
PubChem Compound ID	10106214
PubChem Substance ID	15094483, 24443203, 39745289, 47880100, 47880101, 76765869, 103357936, 127800819, 135650436, 135650838, 136352132, 141344136, 229744205
Target and Pathway
Target(s)	Histamine H1 receptor	Target Info	Antagonist	[526358]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Inflammatory mediator regulation of TRP channels
PANTHER Pathway	Histamine H1 receptor mediated signaling pathway
Reactome	Histamine receptors
Reactome	G alpha (q) signalling events
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	IL-4 Signaling Pathway
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 538720	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1207).
Ref 526358	J Pharmacol Exp Ther. 2002 Jul;302(1):328-36.A novel phenylaminotetralin radioligand reveals a subpopulation of histamine H(1) receptors.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.

Drug Information