Drug Information

Drug General Information
Drug ID
D07FXC
Former ID
DNC006856
Drug Name
2-(3-(3-methoxyphenoxy)prop-1-ynyl)pyridine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528311]
Formula
C15H13NO2
Canonical SMILES
COC1=CC(=CC=C1)OCC#CC2=CC=CC=N2
InChI
1S/C15H13NO2/c1-17-14-8-4-9-15(12-14)18-11-5-7-13-6-2-3-10-16-13/h2-4,6,8-10,12H,11H2,1H3
InChIKey
NUGIZDIFZXSZAH-UHFFFAOYSA-N
PubChem Compound ID
11299421
Target and Pathway
Target(s) Metabotropic glutamate receptor 5 Target Info Inhibitor [528311]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington's disease
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 528311Bioorg Med Chem Lett. 2006 Sep 15;16(18):4792-5. Epub 2006 Jul 12.A new series of pyridinyl-alkynes as antagonists of the metabotropic glutamate receptor 5 (mGluR5).
Ref 528311Bioorg Med Chem Lett. 2006 Sep 15;16(18):4792-5. Epub 2006 Jul 12.A new series of pyridinyl-alkynes as antagonists of the metabotropic glutamate receptor 5 (mGluR5).

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