Drug Information

Drug General Information
Drug ID
D07FTI
Former ID
DIB021255
Drug Name
zinc pyrithione
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539674]
Formula
C10H8N2O2S2Zn
InChI
InChI=1S/2C5H5NOS.Zn/c2*7-6-4-2-1-3-5(6)8;/h2*1-4,8H;/q;;+2/p-2
InChIKey
OTPSWLRZXRHDNX-UHFFFAOYSA-L
PubChem Compound ID
415267
PubChem Substance ID
8137040, 77075702, 210279739, 210282062
Target and Pathway
Target(s) Kv7.5 Target Info Activator [528790]
Potassium voltage-gated channel subfamily KQT member 4 Target Info Activator [528790]
Potassium voltage-gated channel subfamily KQT member 1 Target Info Activator [528790]
Potassium voltage-gated channel subfamily KQT member 2 Target Info Activator [528790]
KEGG Pathway Cholinergic synapsehsa04261:Adrenergic signaling in cardiomyocytes
Cholinergic synapse
Gastric acid secretion
Pancreatic secretion
Protein digestion and absorption
Vibrio cholerae infectionhsa04725:Cholinergic synapse
PANTHER Pathway Muscarinic acetylcholine receptor 1 and 3 signaling pathway
PathWhiz Pathway Muscle/Heart Contraction
Reactome Voltage gated Potassium channelsR-HSA-1296072:Voltage gated Potassium channelsR-HSA-1296072:Voltage gated Potassium channels
Interaction between L1 and Ankyrins
WikiPathways Potassium ChannelsWP706:SIDS Susceptibility Pathways
Potassium Channels
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
TarBasePathwayWP2669:Potassium Channels
L1CAM interactions
References
Ref 539674(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2597).
Ref 528790Zinc pyrithione-mediated activation of voltage-gated KCNQ potassium channels rescues epileptogenic mutants. Nat Chem Biol. 2007 May;3(5):287-96. Epub 2007 Apr 15.

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