Drug Information

Drug General Information
Drug ID
D07CQJ
Former ID
DIB000212
Drug Name
F-50040
Synonyms
Metastatic melanoma vaccine, Pierre Fabre; P40-ELA; Metastatic melanoma vaccine, BioMerieux-Pierre Fabre; Vaccine (melanoma), Pierre Fabre; Vaccine (melanoma), BioMerieux-Pierre Fabre
Indication Melanoma [ICD9: 172; ICD10:C43] Discontinued in Phase 1 [547414]
Company
Pierre Fabre SA
Target and Pathway
Target(s) MART-1 melanoma antigen Target Info Modulator [526271]
Toll-like receptor 2 Target Info Modulator [526271]
KEGG Pathway Phagosome
PI3K-Akt signaling pathway
Toll-like receptor signaling pathway
Legionellosis
Leishmaniasis
Chagas disease (American trypanosomiasis)
Malaria
Toxoplasmosis
Amoebiasis
Tuberculosis
Hepatitis B
Measles
Herpes simplex infection
Proteoglycans in cancer
Inflammatory bowel disease (IBD)
Rheumatoid arthritis
NetPath Pathway IL4 Signaling Pathway
TCR Signaling Pathway
PANTHER Pathway Toll receptor signaling pathway
Pathway Interaction Database Endogenous TLR signaling
Reactome Beta defensins
MyD88:Mal cascade initiated on plasma membrane
Toll Like Receptor TLR6:TLR2 Cascade
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
WikiPathways Toll-like receptor signaling pathway
IL1 and megakaryotyces in obesity
Human Complement System
Toll-Like Receptors Cascades
MyD88:Mal cascade initiated on plasma membrane
Defensins
Regulation of toll-like receptor signaling pathway
References
Ref 547414Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800016041)
Ref 526271Stability and CTL-activity of P40/ELA melanoma vaccine candidate. Biologicals. 2001 Sep-Dec;29(3-4):293-8.

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