Drug Information

Drug General Information
Drug ID
D07BKH
Former ID
DIB018081
Drug Name
(hydroxymethylphenyl)agomelatine
Synonyms
compound 21 [PMID: 18778943]
Drug Type
Small molecular drug
Indication Discovery agent Investigative [542841]
Formula
C22H23NO3
InChI
InChI=1S/C22H23NO3/c1-15(25)23-9-8-19-12-20(17-5-3-4-16(10-17)14-24)11-18-6-7-21(26-2)13-22(18)19/h3-7,10-13,24H,8-9,14H2,1-2H3,(H,23,25)
InChIKey
BHDVJMSEODZSTD-UHFFFAOYSA-N
PubChem Compound ID
9798456
PubChem Substance ID
14754170, 24107908, 44834463, 79784130, 103625143, 104111912, 231704973, 244882751, 249565605
Target and Pathway
Target(s) Melatonin receptor Target Info Antagonist [529678]
KEGG Pathway Neuroactive ligand-receptor interaction
Circadian entrainment
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 542841(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7922).
Ref 529678Synthesis of 3-phenylnaphthalenic derivatives as new selective MT(2) melatoninergic ligands. Bioorg Med Chem. 2008 Sep 15;16(18):8339-48.

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