Drug Information

Drug General Information
Drug ID
D06XLC
Former ID
DIB006944
Drug Name
BMS-739562
Synonyms
BMS-739562; Pyrrolo triazine-based aurora kinase inhibitors (cancer); Pyrrolo triazine-based aurora kinase inhibitors (cancer), Bristol-Myers Squibb
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Investigative [543524]
Company
Bristol-Myers Squibb Co
Target and Pathway
Target(s) Aurora protein kinase Target Info Inhibitor [543524]
KEGG Pathway Oocyte meiosis
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteins
References
Ref 543524(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1936).
Ref 543524(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1936).

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