Drug Information

Drug General Information
Drug ID
D06WZG
Former ID
DNC011337
Drug Name
8-acetyl-7-ethoxy-2H-chromen-2-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531259]
Formula
C13H12O4
Canonical SMILES
CCOC1=C(C2=C(C=C1)C=CC(=O)O2)C(=O)C
InChI
1S/C13H12O4/c1-3-16-10-6-4-9-5-7-11(15)17-13(9)12(10)8(2)14/h4-7H,3H2,1-2H3
InChIKey
KWMPAFCHEJYQEQ-UHFFFAOYSA-N
PubChem Compound ID
50925425
Target and Pathway
Target(s) Carbonic anhydrase IX Target Info Inhibitor [531259]
KEGG Pathway Nitrogen metabolism
Pathway Interaction Database HIF-1-alpha transcription factor network
Reactome Regulation of gene expression by Hypoxia-inducible Factor
Reversible hydration of carbon dioxide
WikiPathways Vitamin D Receptor Pathway
Reversible Hydration of Carbon Dioxide
Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
References
Ref 531259Bioorg Med Chem Lett. 2010 Dec 15;20(24):7255-8. Epub 2010 Oct 25.7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range.
Ref 531259Bioorg Med Chem Lett. 2010 Dec 15;20(24):7255-8. Epub 2010 Oct 25.7,8-disubstituted- but not 6,7-disubstituted coumarins selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic ones I and II in the low nanomolar/subnanomolar range.

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