Drug Information

Drug General Information
Drug ID
D06VST
Former ID
DNC004147
Drug Name
3-Methyl-7-pyrrolidin-1-yl-hept-5-yn-2-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551235]
Formula
C12H19NO
Canonical SMILES
CC(CC#CCN1CCCC1)C(=O)C
InChI
1S/C12H19NO/c1-11(12(2)14)7-3-4-8-13-9-5-6-10-13/h11H,5-10H2,1-2H3
InChIKey
FFWLTEFDRQBMQC-UHFFFAOYSA-N
PubChem Compound ID
15685977
Target and Pathway
Target(s) Muscarinic acetylcholine receptor M2 Target Info Inhibitor [551235]
Muscarinic acetylcholine receptor M1 Target Info Inhibitor [551235]
Muscarinic acetylcholine receptor M4 Target Info Inhibitor [551235]
Muscarinic acetylcholine receptor M3 Target Info Inhibitor [551235]
Muscarinic acetylcholine receptor M5 Target Info Inhibitor [551235]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Cholinergic synapse
Regulation of actin cytoskeletonhsa04020:Calcium signaling pathway
Regulation of actin cytoskeletonhsa04080:Neuroactive ligand-receptor interaction
Regulation of actin cytoskeleton
Insulin secretion
Salivary secretion
Gastric acid secretion
Pancreatic secretionhsa04020:Calcium signaling pathway
PANTHER Pathway Alzheimer disease-amyloid secretase pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
PathWhiz Pathway Muscle/Heart ContractionPW000565:Gastric Acid Production
Reactome Muscarinic acetylcholine receptors
G alpha (i) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
G alpha (q) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
Acetylcholine regulates insulin secretion
G alpha (q) signalling events
WikiPathways SIDS Susceptibility Pathways
Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP58:Monoamine GPCRs
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
GPCR downstream signalingWP58:Monoamine GPCRs
Integration of energy metabolism
References
Ref 551235Cholinergic agents: aldehyde, ketone, and oxime analogues of the muscarinic agonist UH5, Bioorg. Med. Chem. Lett. 2(8):803-808 (1992).
Ref 551235Cholinergic agents: aldehyde, ketone, and oxime analogues of the muscarinic agonist UH5, Bioorg. Med. Chem. Lett. 2(8):803-808 (1992).

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