Drug Information

Drug General Information
Drug ID
D06TVC
Former ID
DIB000174
Drug Name
Tienoxolol
Synonyms
UP-788-42
Drug Type
Small molecular drug
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Discontinued in Phase 2 [544571]
Company
Laboratories UPSA
Formula
C21H28N2O5S
Canonical SMILES
c1(C(=O)OCC)c(OCC(CNC(C)(C)C)O)ccc(NC(=O)c2sccc2)c1
CAS Number
CAS 90055-97-3
PubChem Compound ID
65678
Target and Pathway
Target(s) Beta-3 adrenergic receptor Target Info Modulator [533973]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Salivary secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta3 adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 544571Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000171)
Ref 533973Effects of the beta-adrenoceptor antagonists atenolol and propranolol on human parotid and submandibular-sublingual salivary secretion. J Dent Res. 1994 Jan;73(1):5-10.

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