Drug Information

Drug General Information
Drug ID
D06SKK
Former ID
DNC011116
Drug Name
JWH-440
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531027]
Formula
C21H34O2
Canonical SMILES
CCCCCC(C)(C)C1=CC(=C(C=C1)C2CCCC(C2)O)OC
InChI
1S/C21H34O2/c1-5-6-7-13-21(2,3)17-11-12-19(20(15-17)23-4)16-9-8-10-18(22)14-16/h11-12,15-16,18,22H,5-10,13-14H2,1-4H3/t16-,18+/m0/s1
InChIKey
GZSDLXNECOWUFY-FUHWJXTLSA-N
PubChem Compound ID
46918944
Target and Pathway
Target(s) Cannabinoid receptor 1 Target Info Inhibitor [531027]
Cannabinoid receptor 2 Target Info Inhibitor [531027]
KEGG Pathway Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signalinghsa04080:Neuroactive ligand-receptor interaction
PANTHER Pathway Endogenous cannabinoid signaling
Pathway Interaction Database N-cadherin signaling events
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling eventsR-HSA-373076:Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
BDNF signaling pathway
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP455:GPCRs, Class A Rhodopsin-like
References
Ref 531027Bioorg Med Chem. 2010 Aug 1;18(15):5475-82. Epub 2010 Jun 22.Synthesis and pharmacology of 1-methoxy analogs of CP-47,497.
Ref 531027Bioorg Med Chem. 2010 Aug 1;18(15):5475-82. Epub 2010 Jun 22.Synthesis and pharmacology of 1-methoxy analogs of CP-47,497.

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