Drug Information

Drug General Information
Drug ID
D06RNM
Former ID
DIB019035
Drug Name
burimamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538741]
Formula
C13H18N4S
InChI
InChI=1S/C13H18N4S/c1-14-13(18)15-8-3-2-5-10-6-4-7-12-11(10)9-16-17-12/h4,6-7,9H,2-3,5,8H2,1H3,(H,16,17)(H2,14,15,18)
InChIKey
TXQIYKPZFOKCHA-UHFFFAOYSA-N
PubChem Compound ID
5311293
PubChem Substance ID
7979992, 39340991, 51033434, 85229945, 114155760, 135650034
Target and Pathway
Target(s) Histamine H4 receptor Target Info Antagonist [526144]
Histamine H3 receptor Target Info Antagonist [535111]
Histamine H2 receptor Target Info Agonist [534673]
KEGG Pathway Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gastric acid secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Histamine H2 receptor mediated signaling pathway
PathWhiz Pathway Intracellular Signalling Through Histamine H2 Receptor and Histamine
Gastric Acid Production
Reactome Histamine receptors
G alpha (i) signalling eventsR-HSA-390650:Histamine receptors
G alpha (s) signalling events
WikiPathways GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP727:Monoamine Transport
GPCRs, Class A Rhodopsin-like
GPCR downstream signalingWP58:Monoamine GPCRs
Secretion of Hydrochloric Acid in Parietal Cells
References
Ref 538741(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1229).
Ref 526144Comparison of human, mouse, rat, and guinea pig histamine H4 receptors reveals substantial pharmacological species variation. J Pharmacol Exp Ther. 2001 Oct;299(1):121-30.
Ref 534673Constitutive activity and structural instability of the wild-type human H2 receptor. J Neurochem. 1998 Aug;71(2):799-807.
Ref 535111Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow. Mol Pharmacol. 2001 Mar;59(3):420-6.

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