Drug Information

Drug General Information
Drug ID
D06PHE
Former ID
DIB019657
Drug Name
CPPG
Synonyms
cyclopropyl-4-phosphonophenylglycine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538890]
Formula
C11H14NO5P
InChI
InChI=1S/C11H14NO5P/c12-11(10(13)14,7-1-2-7)8-3-5-9(6-4-8)18(15,16)17/h3-7H,1-2,12H2,(H,13,14)(H2,15,16,17)
InChIKey
IGODGTDUQSMDQU-UHFFFAOYSA-N
PubChem Compound ID
2878
PubChem Substance ID
7372149, 7978532, 8151843, 14824127, 26752002, 29222032, 50690678, 57321493, 85229940, 91746281, 103419560, 104301880, 128164973, 135650134, 135698162, 162209065, 163059084, 174532206, 177749573, 179148482, 204430825, 232996143, 241182027, 241377550
Target and Pathway
Target(s) Metabotropic glutamate receptor 4 Target Info Antagonist [525456]
Metabotropic glutamate receptor 8 Target Info Antagonist [525723]
KEGG Pathway Neuroactive ligand-receptor interaction
Glutamatergic synapse
Taste transductionhsa04080:Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Reactome G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)R-HSA-418594:G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
GPCR ligand binding
GPCR downstream signalingWP501:GPCRs, Class C Metabotropic glutamate, pheromone
GPCR downstream signaling
GPCRs, Other
References
Ref 538890(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1413).
Ref 525456Ligand binding to the amino-terminal domain of the mGluR4 subtype of metabotropic glutamate receptor. J Biol Chem. 1999 Apr 9;274(15):10008-13.
Ref 525723Constraints on proper folding of the amino terminal domains of group III metabotropic glutamate receptors. Brain Res Mol Brain Res. 2000 Mar 10;76(1):180-90.

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