Drug Information

Drug General Information
Drug ID
D06OMW
Former ID
DAP001107
Drug Name
Rasagiline
Synonyms
RAS; Rasagiline [INN]; Azilect (TN); Rasagiline (INN); (1R)-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-inden-1-amine; (1R)-N-prop-2-ynyl-2,3-dihydro-1H-inden-1-amine; (R)-N-2-Propynyl-1-indanamine; 1H-Inden-1-amine, 2,3-dihydro-N-2-propynyl-, (1R)
Drug Type
Small molecular drug
Indication Parkinson's disease [ICD9: 332; ICD10:G20] Approved [536285], [541751]
Therapeutic Class
Antiparkinson Agents
Company
Teva Pharmaceutical Industries Ltd
Formula
C12H13N
InChI
InChI=1S/C12H13N/c1-2-9-13-12-8-7-10-5-3-4-6-11(10)12/h1,3-6,12-13H,7-9H2/t12-/m1/s1
InChIKey
RUOKEQAAGRXIBM-GFCCVEGCSA-N
CAS Number
CAS 136236-51-6
PubChem Compound ID
3052776
PubChem Substance ID
7890222, 7980093, 10056118, 15120458, 15219503, 36118694, 46506045, 46511554, 50070333, 50071312, 56313239, 61269083, 80749168, 92713124, 96025155, 103233337, 111619048, 121277906, 121362276, 126573831, 126625000, 126656198, 126667056, 126732599, 129184029, 132554079, 134338352, 134358863, 135228398, 135611108, 135683150, 136340364, 136373590, 137001346, 142523977, 143493292, 144076117, 151977094, 152165036, 152234171, 160816897, 160964654, 162011569, 162204826, 163090554, 164848146, 172090451, 172859758, 174479357, 175267772
SuperDrug ATC ID
N04BD02
SuperDrug CAS ID
cas=136236516
Target and Pathway
Target(s) Amine oxidase [flavin-containing] B Target Info Inhibitor [537470]
BioCyc Pathway Superpathway of tryptophan utilization
Tryptophan degradation via tryptamine
Dopamine degradation
Putrescine degradation III
Noradrenaline and adrenaline degradation
KEGG Pathway Glycine, serine and threonine metabolism
Arginine and proline metabolism
Histidine metabolism
Tyrosine metabolism
Phenylalanine metabolism
Tryptophan metabolism
Drug metabolism - cytochrome P450
Metabolic pathways
Serotonergic synapse
Dopaminergic synapse
Cocaine addiction
Amphetamine addiction
Alcoholism
PANTHER Pathway Adrenaline and noradrenaline biosynthesis
5-Hydroxytryptamine degredation
Dopamine receptor mediated signaling pathway
Pathway Interaction Database Alpha-synuclein signaling
WikiPathways Tryptophan metabolism
Dopamine metabolism
Phase 1 - Functionalization of compounds
References
Ref 536285Novel pharmacological targets for the treatment of Parkinson's disease. Nat Rev Drug Discov. 2006 Oct;5(10):845-54.
Ref 541751(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6641).
Ref 537470Glyceraldehyde-3-Phosphate Dehydrogenase-Monoamine Oxidase B-Mediated Cell Death-Induced by Ethanol is Prevented by Rasagiline and 1-R-Aminoindan. Neurotox Res. 2009 Aug;16(2):148-59. Epub 2009 May 28.

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