Drug Information

Drug General Information
Drug ID
D06OFD
Former ID
DIB016889
Drug Name
BAY-85-8102
Synonyms
Benzodiazepine receptor agonist (brain disease imaging), University of Sydney; DPA-714-[18F]; F-18 DPA-714; Fluorine-18-DPA-714; Translocator protein-specific ligand (brain disease imaging), University of Sydney; 18F-DPA-714
Indication Brain diseases [ICD10:G00-G99] Phase 1 [522842]
Company
University of Sydney
Canonical SMILES
c1c(nc2n(c1C)nc(c2CC(=O)N(CC)CC)c1ccc(cc1)OCC[18F])C
Target and Pathway
Target(s) Peripheral-type benzodiazepine receptor Target Info Agonist [543743]
KEGG Pathway Neuroactive ligand-receptor interaction
HTLV-I infection
References
Ref 522842ClinicalTrials.gov (NCT01009359) Evaluation of the Neuroinflammation Pattern of BAY85-8102 F-18, DPA-714 in Probable Alzheimers Disease Patients Versus Healthy Volunteers and Radiation Dosimetry of F18, DPA-714 in Healthy Volunteers. U.S. National Institutes of Health.
Ref 543743(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2879).

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