Drug Information

Drug General Information
Drug ID
D06LFV
Former ID
DCL000179
Drug Name
NM-702
Drug Type
Small molecular drug
Indication Angina pectoris [ICD9: 413; ICD10:I20] Phase 3 [544180]
Company
Nissan Chemical America
Formula
C19H19BrCl2N4O2
Canonical SMILES
C1=CC(=CN=C1)CNC2=C(C(=O)NN=C2OCCCC3=CC=C(C=C3)Cl)Br.Cl
InChIKey
QWGUGDYWUADMGB-UHFFFAOYSA-N
CAS Number
CAS 878796-94-2
PubChem Compound ID
9848253
PubChem Substance ID
14810325, 24144883, 44946319, 79967329, 125259484, 135262323, 227920291
Target and Pathway
Target(s) Phosphodiesterase Target Info Inhibitor [536325]
Thromboxane-A synthase Target Info Inhibitor [536325]
BioCyc Pathway C20 prostanoid biosynthesis
KEGG Pathway Arachidonic acid metabolism
Metabolic pathways
Platelet activation
PathWhiz Pathway Arachidonic Acid Metabolism
WikiPathways Prostaglandin Synthesis and Regulation
Arachidonic acid metabolism
Phase 1 - Functionalization of compounds
Eicosanoid Synthesis
References
Ref 544180Application of adaptive design and decision making to a phase II trial of a phosphodiesterase inhibitor for the treatment of intermittent claudication. Trials. 2011; 12: 134.
Ref 536325The novel phosphodiesterase inhibitor NM-702 improves claudication-limited exercise performance in patients with peripheral arterial disease. J Am Coll Cardiol. 2006 Dec 19;48(12):2539-45. Epub 2006Nov 28.

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