Drug Information

Drug General Information
Drug ID
D06LAX
Former ID
DIB001517
Drug Name
PGI-02749
Synonyms
PGI-02749; PGI-02776; ZJ-11; ZJ-17; ZJ-43; NAAG peptidase inhibitors (brain injury, schizophrenia, pain); GCPII inhibitors (brain injury, schizophrenia, pain), PsychoGenics; Glutamate carboxypeptidase II inhibitors (brain injury, schizophrenia, pain), PsychoGenics; NAAG peptidase inhibitors (brain injury, schizophrenia, pain), PsychoGenics; N-acetylaspartylglutamate peptidase inhibitors (brain injury, schizophrenia, pain), PsychoGenics
Indication Brain injury [ICD10:S09.90] Investigative [543445]
Company
Acenta Discovery
Canonical SMILES
C(=O)([C@@H](NC(=O)N[C@H](C(=O)O)CCC(=O)O)CC(C)C)O
Target and Pathway
Target(s) Glutamate carboxypeptidase II Target Info Inhibitor [543445]
KEGG Pathway Alanine, aspartate and glutamate metabolism
Metabolic pathways
Vitamin digestion and absorption
NetPath Pathway TCR Signaling Pathway
TNFalpha Signaling Pathway
Reactome Amino acid synthesis and interconversion (transamination)
WikiPathways One Carbon Metabolism
References
Ref 543445(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1606).
Ref 543445(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1606).

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