Drug Information

Drug General Information
Drug ID
D06JMS
Former ID
DNC010143
Drug Name
3-Benzyl-3-methyl-1-phenylazetidine-2,4-dione
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530511]
Formula
C17H15NO2
Canonical SMILES
CC1(C(=O)N(C1=O)C2=CC=CC=C2)CC3=CC=CC=C3
InChI
1S/C17H15NO2/c1-17(12-13-8-4-2-5-9-13)15(19)18(16(17)20)14-10-6-3-7-11-14/h2-11H,12H2,1H3
InChIKey
ZFHCQEMYYXRUAS-UHFFFAOYSA-N
PubChem Compound ID
44626902
Target and Pathway
Target(s) Leukocyte elastase Target Info Inhibitor [530511]
KEGG Pathway Transcriptional misregulation in cancer
Systemic lupus erythematosus
Pathway Interaction Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
C-MYB transcription factor network
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
WikiPathways Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Human Complement System
Degradation of collagen
References
Ref 530511J Med Chem. 2010 Jan 14;53(1):241-53.4-Oxo-beta-lactams (azetidine-2,4-diones) are potent and selective inhibitors of human leukocyte elastase.
Ref 530511J Med Chem. 2010 Jan 14;53(1):241-53.4-Oxo-beta-lactams (azetidine-2,4-diones) are potent and selective inhibitors of human leukocyte elastase.

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