Drug Information

Drug General Information
Drug ID
D06FIT
Former ID
DNCL003011
Drug Name
SB-728-T
Indication Human immunodeficiency virus infection [ICD9: 279.3; ICD10:B20-B26] Phase 1/2 [523810]
Company
Sangamo BioSciences
Target and Pathway
Target(s) C-C chemokinereceptor type 5 Target Info Modulator [544423]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
Endocytosis
Toxoplasmosis
Viral carcinogenesis
NetPath Pathway TSLP Signaling Pathway
TCR Signaling Pathway
IL2 Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Pathway Interaction Database IL12-mediated signaling events
Reactome Binding and entry of HIV virion
Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways TCR Signaling Pathway
GPCRs, Class A Rhodopsin-like
HIV Life Cycle
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 523810ClinicalTrials.gov (NCT01543152) Dose Escalation Study of Cyclophosphamide in HIV-Infected Subjects on HAART Receiving SB-728-T. U.S. National Institutes of Health.
Ref 544423Gene Editing of CCR5 in Autologous CD4 T Cells of Persons Infected with HIV. N Engl J Med. 2014 March 6; 370(10): 901-910.

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