Drug Information

Drug General Information
Drug ID
D06EUJ
Former ID
DNC012998
Drug Name
3-butoxycarbonyl-4-quinolone
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528134]
Formula
C14H15NO3
Canonical SMILES
CCCCOC(=O)C1=CNC2=CC=CC=C2C1=O
InChI
1S/C14H15NO3/c1-2-3-8-18-14(17)11-9-15-12-7-5-4-6-10(12)13(11)16/h4-7,9H,2-3,8H2,1H3,(H,15,16)
InChIKey
LKWHYYPRQAIKDW-UHFFFAOYSA-N
PubChem Compound ID
11630136
Target and Pathway
Target(s) Gamma-aminobutyric acid receptor subunit alpha-1 Target Info Inhibitor [528134]
Gamma-aminobutyric acid receptor Target Info Inhibitor [528134]
Gamma-aminobutyric acid receptor subunit gamma-2 Target Info Inhibitor [528134]
Gamma-aminobutyric acid receptor subunit beta-2 Target Info Inhibitor [528134]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
Serotonergic synapse
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transport
References
Ref 528134J Med Chem. 2006 Apr 20;49(8):2526-33.4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore modeling.
Ref 528134J Med Chem. 2006 Apr 20;49(8):2526-33.4-quinolone derivatives: high-affinity ligands at the benzodiazepine site of brain GABA A receptors. synthesis, pharmacology, and pharmacophore modeling.

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