TTD | Drug: D06EUH

Drug General Information
Drug ID	D06EUH
Former ID	DIB018123
Drug Name	[11C]doxepin
Synonyms	[11C]-doxepin
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[540579]
Formula	C19H21NO
InChI	InChI=1S/C19H21NO/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19/h3-6,8-12H,7,13-14H2,1-2H3/b17-11+
InChIKey	ODQWQRRAPPTVAG-GZTJUZNOSA-N
PubChem Compound ID	667477
Target and Pathway
Target(s)	Histamine H1 receptor	Target Info	Antagonist	[527045]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Inflammatory mediator regulation of TRP channels
PANTHER Pathway	Histamine H1 receptor mediated signaling pathway
Reactome	Histamine receptors
Reactome	G alpha (q) signalling events
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	IL-4 Signaling Pathway
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 540579	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3958).
Ref 527045	Evaluation of in vivo selective binding of [11C]doxepin to histamine H1 receptors in five animal species. Nucl Med Biol. 2004 May;31(4):493-502.

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Drug Information