Drug Information

Drug General Information
Drug ID
D06EQN
Former ID
DIB014983
Drug Name
XR-510
Drug Type
Small molecular drug
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Terminated [545812]
Company
Xenova Ltd
Formula
C39H48FN5O6S
Canonical SMILES
S(=O)(=O)([N-]C(=O)OCCC(C)C)c1c(c2cc(c(Cn3c(c(nc3CCC)CC<br />)C(=O)CCN(C(=O)CCC)c3cnccc3)cc2)F)cccc1.[K+]
CAS Number
CAS 169181-38-8
PubChem Compound ID
9896750
Target and Pathway
Target(s) Type-1 angiotensin II receptor Target Info Modulator [534102]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Renin-angiotensin system
Renin secretion
Pathways in cancer
NetPath Pathway TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Angiotensin II-stimulated signaling through G proteins and beta-arrestin
Pathway Interaction Database Arf6 trafficking events
Arf6 signaling events
Angiopoietin receptor Tie2-mediated signaling
PathWhiz Pathway Angiotensin Metabolism
Muscle/Heart Contraction
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways ACE Inhibitor Pathway
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
Allograft Rejection
GPCR ligand binding
GPCR downstream signaling
References
Ref 545812Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004861)
Ref 534102Pharmacology of XR510, a potent orally active nonpeptide angiotensin II AT1 receptor antagonist with high affinity for the AT2 receptor subtype. J Cardiovasc Pharmacol. 1995 Sep;26(3):354-62.

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