Drug Information

Drug General Information
Drug ID
D06CWM
Former ID
DIB010795
Drug Name
AZD-7507
Synonyms
AZ-683; AZD-7507; CSF-1R inhibitors (cancer); CSF-1R inhibitors (cancer), AstraZeneca; Colony stimulating factor-1 receptor inhibitors (cancer), AstraZeneca
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Investigative [543466]
Company
AstraZeneca plc
Canonical SMILES
c1(c(cc2c(c1)c(c(cn2)C(=O)N)Nc1c(cc(cc1)F)F)OCC)N1CCN(C<br />C1)C
Target and Pathway
Target(s) Macrophage colony-stimulating factor receptor Target Info Inhibitor [543466]
KEGG Pathway Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
Jak-STAT signaling pathway
Hematopoietic cell lineage
Pathways in cancer
NetPath Pathway Leptin Signaling Pathway
RANKL Signaling Pathway
References
Ref 543466(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1719).
Ref 543466(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1719).

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