Drug Information

Drug General Information
Drug ID
D06BUA
Former ID
DIB002912
Drug Name
Nexopamil
Synonyms
LU-49938
Drug Type
Small molecular drug
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Phase 2 [533605]
Company
BASF AG
Formula
C24H40N2O3
Canonical SMILES
c1([C@@](C#N)(C(C)C)CCCN(CCCCCC)C)cc(c(c(c1)OC)OC)OC
PubChem Compound ID
65984
Target and Pathway
Target(s) Calcium channel Target Info Blocker [533605]
5-HT 2 receptor Target Info Modulator [533605]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channels
References
Ref 533605Inhibition by the combined Ca2+ and 5-HT2 receptor antagonist nexopamil (LU 49938) of intracoronary thrombus formation in a canine model of arterial stenosis and intimal damage. J Cardiovasc Pharmacol. 1993 Nov;22(5):687-94.
Ref 533605Inhibition by the combined Ca2+ and 5-HT2 receptor antagonist nexopamil (LU 49938) of intracoronary thrombus formation in a canine model of arterial stenosis and intimal damage. J Cardiovasc Pharmacol. 1993 Nov;22(5):687-94.

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