Drug Information

Drug General Information
Drug ID
D06AYN
Former ID
DIB019995
Drug Name
HAMI3379
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541369]
Formula
C34H45NO8
InChI
InChI=1S/C34H45NO8/c36-32(35-27-10-6-9-25(22-27)33(37)38)30-23-26(34(39)40)15-18-31(30)43-21-7-8-24-13-16-29(17-14-24)42-20-5-4-19-41-28-11-2-1-3-12-28/h13-18,23,25,27-28H,1-12,19-22H2,(H,35,36)(H,37,38)(H,39,40)
InChIKey
HRJWSEPIRZRGCL-UHFFFAOYSA-N
PubChem Compound ID
10438479
PubChem Substance ID
15458319, 22777418, 40566135, 77691000, 125334000, 137402929, 139222572, 178102818, 230440612, 244555091
Target and Pathway
Target(s) Leukotriene CysLT2 receptor Target Info Antagonist [530873]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway IL4 Signaling Pathway
IL3 Signaling Pathway
Pathway Interaction Database Endothelins
Reactome Leukotriene receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 541369(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6197).
Ref 530873Pharmacological characterization of the first potent and selective antagonist at the cysteinyl leukotriene 2 (CysLT(2)) receptor. Br J Pharmacol. 2010 May;160(2):399-409.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.