Drug Information

Drug General Information
Drug ID
D05ZXS
Former ID
DIB009529
Drug Name
MAXY-G34
Synonyms
Maxy-G21; MAXY-G-CSF; G-CSF agonist (neutropenia, leukopenia), Maxygen
Indication Neutropenia [ICD9: 288; ICD10:D70] Phase 2 [522065]
Company
Maxygen
Target and Pathway
Target(s) Macrophage colony-stimulating factor receptor Target Info Agonist [532564]
KEGG Pathway Cytokine-cytokine receptor interaction
PI3K-Akt signaling pathway
Jak-STAT signaling pathway
Hematopoietic cell lineage
Pathways in cancer
NetPath Pathway Leptin Signaling Pathway
RANKL Signaling Pathway
References
Ref 522065ClinicalTrials.gov (NCT00501332) Evaluation of Maxy-G34 in Breast Cancer Patients Treated With TAC (Docetaxel, Adriamycin, Cyclophosphamide) Chemotherapy. U.S. National Institutes of Health.
Ref 532564Survival efficacy of the PEGylated G-CSFs Maxy-G34 and neulasta in a mouse model of lethal H-ARS, and residual bone marrow damage in treated survivors. Health Phys. 2014 Jan;106(1):21-38.

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