Drug Information

Drug General Information
Drug ID
D05XVM
Former ID
DNC004052
Drug Name
1-Methoxy-6-phenyl-6H-benzo[c]chromen-8-ylamine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527034]
Formula
C20H17NO2
Canonical SMILES
COC1=CC=CC2=C1C3=C(C=C(C=C3)N)C(O2)C4=CC=CC=C4
InChI
1S/C20H17NO2/c1-22-17-8-5-9-18-19(17)15-11-10-14(21)12-16(15)20(23-18)13-6-3-2-4-7-13/h2-12,20H,21H2,1H3
InChIKey
MVULNNIYAGEMCC-UHFFFAOYSA-N
PubChem Compound ID
18189209
Target and Pathway
Target(s) mRNA of glucocorticoid receptor Target Info Inhibitor [527034]
KEGG Pathway Neuroactive ligand-receptor interaction
NetPath Pathway IL2 Signaling Pathway
TCR Signaling Pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Signaling events mediated by HDAC Class II
FOXA2 and FOXA3 transcription factor networks
Glucocorticoid receptor regulatory network
Regulation of Androgen receptor activity
AP-1 transcription factor network
Reactome BMAL1:CLOCK,NPAS2 activates circadian gene expression
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
SIDS Susceptibility Pathways
Endoderm Differentiation
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Adipogenesis
Circadian Clock
Nuclear Receptors
References
Ref 527034Bioorg Med Chem Lett. 2004 May 3;14(9):2079-82.Synthesis and biological evaluation of novel, selective, nonsteroidal glucocorticoid receptor antagonists.
Ref 527034Bioorg Med Chem Lett. 2004 May 3;14(9):2079-82.Synthesis and biological evaluation of novel, selective, nonsteroidal glucocorticoid receptor antagonists.

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