Drug Information

Drug General Information
Drug ID
D05SYO
Former ID
DIB002222
Drug Name
KR-33889
Synonyms
KR-34285; PARP-1 inhibitors (myocardial infarction), KRICT
Indication Myocardial infarction [ICD9: 410; ICD10:I21, I22] Investigative [543709]
Company
Korea Research Institute of Chemical Technology
Canonical SMILES
c1cc(c2c(c1)[nH]c(n2)SC(c1ccc(cc1)OC)C(=O)OC)C(=O)N
Target and Pathway
Target(s) Poly [ADP-ribose] polymerase-1 Target Info Inhibitor [543709]
KEGG Pathway Base excision repair
NF-kappa B signaling pathway
PANTHER Pathway FAS signaling pathway
Pathway Interaction Database Integrin-linked kinase signaling
Caspase Cascade in Apoptosis
Notch-mediated HES/HEY network
Reactome Dual Incision in GG-NER
WikiPathways FAS pathway and Stress induction of HSP regulation
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Nanoparticle triggered regulated necrosis
Corticotropin-releasing hormone
References
Ref 543709(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2771).
Ref 543709(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2771).

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