Drug Information

Drug General Information
Drug ID
D05SYL
Former ID
DIB019678
Drug Name
CYM5181
Synonyms
CYM-5181
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539944]
Formula
C17H17N3O3
InChI
InChI=1S/C17H17N3O3/c1-3-21-14-6-5-13(11-15(14)22-4-2)17-19-16(20-23-17)12-7-9-18-10-8-12/h5-11H,3-4H2,1-2H3
InChIKey
MMKXHTDCKLZHIM-UHFFFAOYSA-N
PubChem Compound ID
976135
PubChem Substance ID
1238496, 3611015, 4258673, 5258826, 7959542, 8723962, 44262392, 49803201, 57959680, 77084640, 89135625, 106275750, 110124814, 112379035, 118266139, 124583697, 124836993, 135650149, 136915274, 140449804, 170268523, 179359002, 238413727, 242257066, 247499265, 250016913, 252618086
Target and Pathway
Target(s) Sphingosine 1-phosphate receptor 1 Target Info Agonist [529645]
KEGG Pathway FoxO signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway IL4 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
IL2 Signaling Pathway
Pathway Interaction Database Fc-epsilon receptor I signaling in mast cells
S1P3 pathway
S1P1 pathway
Sphingosine 1-phosphate (S1P) pathway
PDGFR-beta signaling pathway
Reactome G alpha (i) signalling events
Lysosphingolipid and LPA receptors
WikiPathways Signal Transduction of S1P Receptor
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 539944(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2927).
Ref 529645Full pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like headgroup interactions. Mol Pharmacol. 2008 Nov;74(5):1308-18.

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