Drug Information

Drug General Information
Drug ID
D05RWD
Former ID
DIB002984
Drug Name
Research programme: farnesoid X receptor agonists, Roche
Synonyms
Farnesoid X receptor agonists (dyslipidemia/diabetes); FXR agonists (dyslipidemia/ diabetes), Roche; Farnesoid X receptor agonists (dyslipidemia/diabetes), Roche
Indication Diabetes [ICD9: 253.5, 588.1; ICD10:E23.2, N25.1] Investigative [543895]
Company
Roche Holding AG
Canonical SMILES
c1(c(cc2c(c1)nc(n2[C@H](C(=O)Nc1ccc(cc1F)C(=O)O)C1CCCCC<br />1)c1ccc(cc1)Cl)F)F
Target and Pathway
Target(s) Bile acid receptor Target Info Agonist [543895]
KEGG Pathway Bile secretion
Pathway Interaction Database RXR and RAR heterodimerization with other nuclear receptor
Reactome Recycling of bile acids and salts
PPARA activates gene expression
Endogenous sterols
WikiPathways Nuclear Receptors in Lipid Metabolism and Toxicity
Nuclear Receptors Meta-Pathway
Farnesoid X Receptor Pathway
Drug Induction of Bile Acid Pathway
References
Ref 543895(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 603).
Ref 543895(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 603).

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.