Drug Information

Drug General Information
Drug ID
D05QTX
Former ID
DIB020626
Drug Name
Org27569
Synonyms
Org 27569
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531984]
Formula
C24H28ClN3O
InChI
InChI=1S/C24H28ClN3O/c1-2-20-21-16-18(25)8-11-22(21)27-23(20)24(29)26-13-12-17-6-9-19(10-7-17)28-14-4-3-5-15-28/h6-11,16,27H,2-5,12-15H2,1H3,(H,26,29)
InChIKey
AHFZDNYNXFMRFQ-UHFFFAOYSA-N
PubChem Compound ID
44828492
PubChem Substance ID
90341443, 104253193, 120140535, 124757323, 125164127, 135698815, 136348244, 136367539, 152258523, 160647358, 160698730, 160869022, 162011818, 162038062, 162205096, 163122471, 163564970, 174531084, 176238999, 178233167, 185972545, 188919889, 204362481, 215783629, 223366181, 223601165, 242059896, 246776465, 249797656, 252079880, 252156902, 252215959
Target and Pathway
Target(s) Cannabinoid receptor 1 Target Info Modulator (allosteric modulator) [531899]
KEGG Pathway Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
PANTHER Pathway Endogenous cannabinoid signaling
Pathway Interaction Database N-cadherin signaling events
Reactome Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
BDNF signaling pathway
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 531984A key agonist-induced conformational change in the cannabinoid receptor CB1 is blocked by the allosteric ligand Org 27569. J Biol Chem. 2012 Sep 28;287(40):33873-82. Epub 2012 Jul 30.
Ref 531899Indole-2-carboxamides as allosteric modulators of the cannabinoid CB??receptor. J Med Chem. 2012 Jun 14;55(11):5627-31.

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