Drug Information

Drug General Information
Drug ID
D05QTT
Former ID
DIB021040
Drug Name
tetralin_urea analogue (7o)
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538808]
Formula
C26H31ClFN5O
InChI
InChI=1S/C26H31ClFN5O/c1-31-11-13-32(14-12-31)9-2-10-33(26(34)30-22-6-8-25(28)24(27)17-22)23-7-5-20-4-3-19(18-29)15-21(20)16-23/h3-4,6,8,15,17,23H,2,5,7,9-14,16H2,1H3,(H,30,34)
InChIKey
GQGGDNLJDZHJKN-UHFFFAOYSA-N
PubChem Compound ID
11691555
PubChem Substance ID
16795906, 23786059, 42858473, 79618551, 103502648, 104082550, 135651251, 137620531, 139148375, 224018980, 229957285, 245803549
Target and Pathway
Target(s) Melanin-concentrating hormone receptor 1 Target Info Antagonist [528636]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 538808(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1319).
Ref 528636Discovery of tetralin ureas as potent melanin concentrating hormone 1 receptor antagonists. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1718-21. Epub 2006 Dec 24.

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