Drug Information

Drug General Information
Drug ID
D05PZN
Former ID
DCL001025
Drug Name
TRO-19622
Drug Type
Small molecular drug
Indication Chemotherapy-induced peripheral neuropathy [ICD9: 356.0, 356.8; ICD10:G64, G90.0] Phase 2 [536447], [543190]
Company
Trophos
Formula
C27H45NO
InChI
InChI=1S/C27H45NO/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28-29)13-15-26(20,4)25(22)14-16-27(23,24)5/h17-19,22-25,29H,6-16H2,1-5H3/b28-21-/t19-,22+,23-,24+,25+,26+,27-/m1/s1
InChIKey
QNTASHOAVRSLMD-FCARAQADSA-N
CAS Number
CAS 22033-87-0
PubChem Compound ID
21763506
PubChem Substance ID
37051306, 55443489, 87678864, 109692944, 135263118, 227264157, 249617707, 251965550, 251965833, 252089284, 252156865, 252480340
Target and Pathway
Target(s) Glutamate receptor AMPA subtype Target Info Antagonist [536447]
References
Ref 536447Emerging disease-modifying therapies for the treatment of motor neuron disease/amyotropic lateral sclerosis. Expert Opin Emerg Drugs. 2007 May;12(2):229-52.
Ref 543190(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8542).
Ref 536447Emerging disease-modifying therapies for the treatment of motor neuron disease/amyotropic lateral sclerosis. Expert Opin Emerg Drugs. 2007 May;12(2):229-52.

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