Drug Information

Drug General Information
Drug ID
D05NRI
Former ID
DIB001274
Drug Name
Ceronapril
Synonyms
Ceranapril; SQ-29852
Drug Type
Small molecular drug
Indication Major depressive disorder [ICD9: 296.2, 296.3, 710.0; ICD10:F32, F33, M32] Discontinued in Phase 2 [544627]
Company
Bristol-Myers Squibb Co
Formula
C21H33N2O6P
Canonical SMILES
N1(C(=O)[C@@H](OP(=O)(O)CCCCc2ccccc2)CCCCN)[C@H](C(=O)O<br />)CCC1
CAS Number
CAS 111223-26-8
PubChem Compound ID
189729
Target and Pathway
Target(s) Angiotensin-converting enzyme Target Info Inhibitor [526817]
KEGG Pathway Renin-angiotensin system
Chagas disease (American trypanosomiasis)
Hypertrophic cardiomyopathy (HCM)
PathWhiz Pathway Angiotensin Metabolism
Reactome Metabolism of Angiotensinogen to Angiotensins
WikiPathways ACE Inhibitor Pathway
Metabolism of Angiotensinogen to Angiotensins
References
Ref 544627Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000355)
Ref 526817Radioimmunoassay for ceronapril, a new angiotensin-converting enzyme inhibitor, and its application to a pharmacokinetic study in healthy male volunteers. Ther Drug Monit. 1992 Jun;14(3):209-19.

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