Drug Information

Drug General Information
Drug ID
D05LKZ
Former ID
DIB012486
Drug Name
HPP-607
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Phase 1 [522723]
Company
TransTech Pharma Inc
Target and Pathway
Target(s) Aurora protein kinase Target Info Inhibitor [543524]
KEGG Pathway Oocyte meiosis
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteins
References
Ref 522723ClinicalTrials.gov (NCT00939172) TTP607 in Refractory Solid Malignancies. U.S. National Institutes of Health.
Ref 543524(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1936).

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